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Anti-aging researchAnti aging research. I-Aging Effects of CarnosineLife Extension Magazine, January 2003 Telomere Control and Cellular AgingLife Extension Magazine, October 2002 William Haseltine, Founder, Chairman of the Board, and CEO, Human Genome SciencesLife Extension Magazine, June 2002 Discovering the Genetic Controls that Dictate Life SpanLife Extension Magazine, June 2002 DHEA and Anti-Aging MedicineLife Extension Magazine, June 2002 Reversing Aging Rapidly with Short Term Calorie RestrictionLife Extension Magazine, October 2001 The Buck Institute for Age ResearchLife Extension Magazine, October 2001 AGE BreakersLife Extension Magazine, August 2001 Bioenergetic Therapy for AgingMitochondria hold the key to cellular life and deathLife Extension Magazine, February 2001 Carnosine and Cellular SenescenceWhat the life cycles of cells and proteins tell us about mortalityLife Extension Magazine, January 2001 CARNOSINENature's pluripotent life extension agentby Karin Granstrom Jordan, M.D., LE Magazine, January 2001 REINVENTING THE BRAINLE Magazine's contributor, Terri Mitchell, interviews Dr. Gage.Life Extension Magazine, August 2000 The Antiaging Effects of Acetyl-L-CarnitineNew Research Yields Unexpected BenefitsLife Extension Magazine, May 2000 Conquering Aging with CloningLife Extension Interviews Michael West on new breakthroughs...Life Extension Magazine, April 2000 Vitamin K Stunning new research shows that vitamin K may be ...by Terri Mitchell, LE Magazine, February 2000 On the Frontiers of ScienceResearch funded by The Life Extension FoundationLife Extension Magazine, February 2000 STAYING YOUNG FOREV![]() |
What is anti-aging?Share key aging-related genes, the paper points to a new direction for human anti-aging research. SIR2 -- and possibly its counterpart in mammals, SIRT1 -- may block the organism from entering an extreme survival mode characterized by the absence of reproduction, improved DNA repair and increased protection against cell damage, Longo suggests. Organisms usually enter this mode in response to starvation. The long-lived organisms in Longo's experiment showed extraordinary resilience under stress. "We hit them with oxidants, we hit them with heat," Longo notes. "They are highly resistant to everything. What they're doing is basically saying, 'I cannot afford to age. I still have to generate offspring, but I don't have enough food to do it now.'" As molecular geneticists master the levers of aging, Longo predicts, they will be able to design drugs that coax the body into entering chosen aspects of a starvation-response mode -- such as stress resistance -- even when food is plentiful. If enough food is available, an organism might be programmed both to reproduce normally and to maximize its survival systems. Longo urges caution in extrapolating the result to humans, though. "We have been very successful with simple organisms," he says. "Naturally, mammals are complex, and it will be a great challenge to get major life-span extension." Speed Up DNA Repair? A "really exciting" implication, Longo says, is that cells may be able to speed up their DNA repair efforts. All organisms have the ability to repair harmful mutations in their DNA, whether caused by age, radiation, diet or oth |
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